US Airways Express - SkyWest Airlines SkyWest Airlines is a North American regional airline headquartered in St. George, Utah. SkyWest is classified as one of the major airlines of the United States and is the largest regional airline in North America when measured by fleet size, number of passengers carried, and number of destinations served. Despite that, SkyWest does not independently operate any flights, instead working on a contract basis with mainline partners. SkyWest is paid to operate and maintain aircraft used on flights that are scheduled, marketed, and priced by a partner airline.
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